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Investigation of Chronic Inflammatory Processes in Male Individuals With Hypohidrotic Ectodermal Dysplasia

NCT01308333 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2014-01-08

No results posted yet for this study

Summary

X-linked hypohidrotic ectodermal dysplasia (XLHED) is a complex genetic disorder characterized by lack of sweat, sebaceous, submucous, Meibomian and mammary glands, sparse hair and eyebrows, and oligodontia. Insufficient function of the respective glands may lead to chronic inflammatory processes in airways and eyes of the affected individuals. The investigators will quantify sweat glands of XLHED patients, assess chronic conjunctivitis and blepharitis in conjunction with quantitative and/or qualitative alterations of lacrimal fluid in these subjects, evaluate lung function and assess chronic inflammatory processes in the airways by NO measurements. The data should provide a basis for genotype-phenotype correlations.

Conditions

  • X-linked Hypohidrotic Ectodermal Dysplasia

Sponsors & Collaborators

  • Edimer Pharmaceuticals

    collaborator INDUSTRY

  • University Hospital Erlangen

    lead OTHER

Principal Investigators

  • Holm Schneider, MD · University Hospital Erlangen

Eligibility

Min Age
6 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-04-30
Primary Completion
2011-11-30
Completion
2011-11-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01308333 on ClinicalTrials.gov