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Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia

NCT01109290 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2011-09-14

No results posted yet for this study

Summary

Hypohidrotic ectodermal dysplasia (HED) is a complex genetic disorder characterized by lack of sweat glands, sparse hair, and missing or malformed teeth. Inability to sweat may result in episodes of severe hyperthermia and cause sudden infant death. To assess sweat gland function in HED patients, the investigators will first quantify gland pores in a defined area of the palm and then stimulate the glands by pilocarpine followed by sweat collection in a special capillary for volume determination. This will be combined with non-invasive skin conductance measurement prior and subsequent to stimulation of the sympathetic nervous system. The data should provide a basis for genotype-phenotype correlation.

Conditions

  • Hypohidrotic Ectodermal Dysplasia

Sponsors & Collaborators

  • Edimer Pharmaceuticals

    collaborator INDUSTRY

  • University Hospital Erlangen

    lead OTHER

Principal Investigators

  • Holm Schneider, MD · University Hospital Erlangen

Eligibility

Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-04-30
Primary Completion
2010-08-31
Completion
2011-06-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01109290 on ClinicalTrials.gov