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Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.

NCT01678274 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2016-05-24

No results posted yet for this study

Summary

Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, hypertension, stroke and autoimmune diseases in general.

Our study aim is:

* Using MRI to further characterize and find risk factors leading to aortic dilation.
* Using MRI to assess the degree of aortic distensibility.
* Using Computed tomography x-ray scanning of the heart and coronary arteries to characterize the prevalence and degree of ischemic heart disease and coronary anomalies.
* Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of aortic stiffness when compared to controls using end points as Pulse Wave Velocity, Augmentation Index and Central Pulse Pressure.

Conditions

  • Turner Syndrome
  • Aortic Aneurysm
  • Ischemic Heart Disease
  • Hypertension
  • Congenital Heart Defect

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Claus H Gravholt, MD · Aarhus University Hospital

  • Christian Trolle, MD · Aarhus University Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2016-03-31
Completion
2016-10-31

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01678274 on ClinicalTrials.gov