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Short Term Effects and Risks of Physical Exercise in Subjects With Hypohidrotic Ectodermal Dysplasia

NCT01135888 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2021-08-19

No results posted yet for this study

Summary

Because of their lack of sweat glands individuals with hypohidrotic ectodermal dysplasia (HED) are at particular risk of life-threatening hyperthermia during exercise in a warm environment. In this study, the effects of physical exercise are investigated in boys and male adolescents with X-chromosomally inherited HED as well as age-matched controls, who undergo standardized exertion on a bicycle ergometer at ambient temperatures of 25°C and 30°C. Body core temperature during and after ergometry, heart rate, performance, and serum lactate as a marker of metabolic stress are measured. Subjects with HED are expected to show an endangering rise of body temperature in connection with physical exercise. To clarify, whether novel cooling devices may reduce the likelihood of overheating, the effects of such devices are evaluated at 30°C.

Conditions

  • X-Linked Hypohidrotic Ectodermal Dysplasia
  • Exercise-induced Rise of Body Temperature

Interventions

DEVICE

Skin cooling devices

Cooling vest and cooling bandana

Sponsors & Collaborators

  • Pervormance GmbH

    collaborator UNKNOWN

  • University Hospital Erlangen

    lead OTHER

Principal Investigators

  • Holm Schneider, MD · University Hospital Erlangen

Eligibility

Min Age
7 Years
Max Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2010-02-28
Completion
2010-02-28

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01135888 on ClinicalTrials.gov