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Changes in Insulin Sensitivity After Weight Loss

NCT00627484 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 119

Last updated 2019-09-19

No results posted yet for this study

Summary

This study is designed to compare the changes in insulin sensitivity as well as gastrointestinal hormone levels in diabetic and non-diabetic obese individuals who are undergoing weight loss procedures. The main hypothesis of this study is that weight loss induced by gastric bypass will induce a greater improvement in insulin sensitivity compared with gastric banding or low calorie diet. Subjects will be studied before and after weight loss. Studies consist of intravenous glucose tolerance test, body composition analysis, meal test, and energy expenditure.

Conditions

Interventions

PROCEDURE

Gastric bypass

NOTE: the surgery is not paid for by the study

PROCEDURE

Gastric banding

NOTE: the surgery is not paid for by the study

PROCEDURE

Sleeve gastrectomy

NOTE: the surgery is not paid for by the study

BEHAVIORAL

Very low calorie diet

Weight loss with calorie restricted liquid diet. Subject will be asked to stay in our in-patient research unit for 2-3 weeks and consume only those foods supplied by our bionutrition unit. Expected weight loss should be between 7-10% of body weight. Subjects will receive the diet at no cost and will be compensated for their time.

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Judith Korner, MD,PhD · Columbia University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-03-01
Primary Completion
2018-06-17
Completion
2018-06-17

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00627484 on ClinicalTrials.gov