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Longitudinal Phenotyping of Bariatric Surgery Patients

NCT02421055 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 158

Last updated 2020-11-06

Study results available
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Summary

Recent studies have shown that bacteria within the gut play an important role in diabetes improvement after bariatric (weight-loss) surgery. Bariatric surgery fundamentally changes the environment within the gut, which results in changes to the makeup of the trillions of bacteria living within it. These changes in the gut bacteria can affect the body in a number of complex ways, which we are only just beginning to understand. For example, gut bacteria breakdown food we are unable to absorb ourselves, leading to altered sugar levels and can release molecules that act to reduce appetite.

In this study we aim to find out how bariatric surgery changes the gut bacteria and how this leads to weight loss and improvement of diabetes. With this understanding we hope to discover potential targets for future treatments, such as identifying beneficial bacteria that could be supplemented with probiotics in patients.

Additionally, although highly successful, up to 30% of obese patients do not undergo improvement of their diabetes after bariatric surgery. We aim to identify molecules within the patient's blood or urine that are able to predict the likely chance a patient will undergo improvement in their diabetes after bariatric surgery to help clinicians select patients most likely to benefit.

Conditions

  • Obesity
  • Diabetes Mellitus, Type 2

Interventions

PROCEDURE

Laparoscopic Roux-en-Y Gastric Bypass

PROCEDURE

Laparoscopic Sleeve Gastrectomy

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Ara Darzi, MB, BCh, MD · Imperial College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2019-02-28
Completion
2019-02-28

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02421055 on ClinicalTrials.gov