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Effect of Number of Meals on Metabolism After Weight Loss Surgery

NCT02929212 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2017-02-01

No results posted yet for this study

Summary

The purpose of this study is to determine the effect of meal size and texture on the levels of incretin hormone, GLP-1, after Gastric Bypass Surgery (GBP). Patterns of food intake change after bariatric surgery and patients often eat multiple small low-calorie meals, a pattern that may affect blood glucose as well as incretin levels. Whether the release of GLP-1 after an oral challenge or a single liquid meal has any physiological relevance in 'real life' setting of multiple small meals diet is unclear.

Conditions

  • Morbid Obesity

Interventions

OTHER

Solid Meal

Subjects will receive solid meals during meal study

OTHER

Liquid Meal

Subjects will receive liquid meals, during meal study

DRUG

Acetaminophen

All subjects given acetaminophen to measure gastric emptying

OTHER

Single, 600 kcal meal

Subjects will receive a single, 600 kcal meal during meal study

OTHER

Multiple, 200 kcal meals

Subjects will receive three, 200 kcal meals, during meal study

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Blandine Laferrere, MD · Columbia University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2014-04-30
Completion
2014-04-30

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02929212 on ClinicalTrials.gov