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Incretin Physiology and Beta-cell Function Before and After Weight-loss

NCT00625040 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2014-10-09

No results posted yet for this study

Summary

To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) in morbidly obese patients and to describe the pathophysiological mechanisms involved in the amelioration of glucose homeostasis during long-term weight loss.

Conditions

Interventions

OTHER

Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate

OGTT: The test is performed with 50 g of glucose deluded in 300 ml water Isoglycemic iv. clamp: Iv. glucose infusion mimicking the glucose response curves from the OGTT Liquid Meal test: The test is performed with 100g of formula milk deluded in 300 ml. water Gastric Emptying Rate: Paracetamol absorption test.

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • European Foundation for the Study of Diabetes

    collaborator OTHER

  • Novo Nordisk A/S

    collaborator INDUSTRY

  • Glostrup University Hospital, Copenhagen

    lead OTHER

Principal Investigators

  • Katrine Bagge Hansen, MD · Glostrup University Hospital, Copenhagen

  • Filip K Knop, MD, PhD · Gentofte Hospital

  • Steen Larsen, MD, DMSc · Glostrup University Hospital, Copenhagen

  • Jens Juul Holst, MD,DMSc · University of Copenhagen

  • Viggo Kristensen, MD · Glostrup University Hospital, Copenhagen

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2011-01-31
Completion
2011-01-31

Countries

  • Denmark

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00625040 on ClinicalTrials.gov