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Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery

NCT01271062 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 55

Last updated 2013-03-07

No results posted yet for this study

Summary

Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function. The presented double-centre study aims to comprehensively investigate different aspects of beta cell function in patients with type 2 diabetes (T2DM) with a wide range of disease duration after gastric bypass. In parallel, our project will address the aspects of changes in enteroinsular and adipoinsular axes as well as the early and late changes of other defined parameters after gastric bypass surgery.

Conditions

  • Diabetes Mellitus, Type 2
  • Bariatric Surgery Candidate

Interventions

PROCEDURE

gastric bypass surgery

PROCEDURE

abdominal surgery

BEHAVIORAL

very low caloric diet

Sponsors & Collaborators

  • European Foundation for the Study of Diabetes

    collaborator OTHER

  • Medical University of Graz

    collaborator OTHER

  • Cantonal Hospital of St. Gallen

    lead OTHER

Principal Investigators

  • Bernd Schultes, Prof. · Interdisciplinary Obesity Center, Kantonal Hospital St. Gallen, Switerland

  • Thomas Pieber, Prof. · Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Austria

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2012-11-30
Completion
2012-12-31

Countries

  • Austria
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01271062 on ClinicalTrials.gov