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Physiological Responses to Laparoscopic Sleeve Gastrectomy: Focusing on Ghrelin

NCT04055025 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2024-02-28

No results posted yet for this study

Summary

Our hypothesis is that decreased concentration of ghrelin after LSG is important for the decreased appetite and food intake postoperatively. We therefore expect infusion of ghrelin will increase an ad libitum food intake after LSG. We also expect that a decreased postprandial concentration of ghrelin after LSG play a role for increased insulin secretion and decreased postprandial plasma glucose concentrations after surgery.

Conditions

  • Bariatric Surgery

Interventions

OTHER

Placebo

Four-hour liquid solid meal tests and a subsequent ad libitum meal during saline infusion.

OTHER

Ghrelin

Four-hour liquid solid meal tests and a subsequent ad libitum meal during acyl-ghrelin infusion.

Sponsors & Collaborators

  • Hvidovre University Hospital

    lead OTHER

Principal Investigators

  • Nora Hedbäck, MD · Department of Endocrinology, Hvidovre University Hospital, Denmark

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-02-28
Primary Completion
2022-05-12
Completion
2022-05-20

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04055025 on ClinicalTrials.gov