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Combination Chemotherapy Followed by Radiation Therapy in Treating Children With Localized Ependymoma

NCT00004224 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 65

Last updated 2013-08-26

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with radiation therapy may kill more tumor cells.

PURPOSE: This phase II trial is studying combination chemotherapy and radiation therapy to see how well they work in treating children with localized ependymoma.

Conditions

Interventions

DRUG

cyclophosphamide

DRUG

etoposide

DRUG

vincristine sulfate

PROCEDURE

adjuvant therapy

PROCEDURE

conventional surgery

RADIATION

radiation therapy

Sponsors & Collaborators

  • Children's Cancer and Leukaemia Group

    collaborator OTHER

  • Italian Association for Pediatric Hematology Oncology

    collaborator OTHER

  • Societe Internationale d'Oncologie Pediatrique

    lead OTHER

Principal Investigators

  • Richard Grundy, MD, PhD · Birmingham Children's Hospital

  • Maura Massimino, MD · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Study Design

Purpose
TREATMENT

Eligibility

Min Age
3 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-01-31
Completion
2008-03-31

Countries

  • Argentina
  • Canada
  • Italy
  • Netherlands
  • Spain
  • Sweden
  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00004224 on ClinicalTrials.gov