Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known if chemotherapy is more effective with or without dexrazoxane for Hodgkin's disease.

PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy, with or without dexrazoxane, followed by radiation therapy in treating young patients with newly diagnosed stage I, stage II, or stage III Hodgkin's disease.

Conditions

• Cardiac Toxicity
• Lymphoma

Interventions

BIOLOGICAL

bleomycin sulfate

Given IV

BIOLOGICAL

filgrastim

Given IV

DRUG

dexrazoxane hydrochloride

Given IV

DRUG

doxorubicin hydrochloride

Given IV

DRUG

etoposide

Given IV

DRUG

vincristine sulfate

Given IV

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET electron therapy

RADIATION

low-LET photon therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Children's Cancer Group

  collaborator OTHER

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• Cameron K. Tebbi, MD · St. Joseph's Children's Hospital of Tampa

• Michael A. Weiner, MD · Herbert Irving Comprehensive Cancer Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

SINGLE_GROUP

Eligibility

Max Age

21 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1996-10-31

Primary Completion

2004-10-31

Completion

2008-06-30

Countries

• United States
• Australia
• Canada

Study Locations