Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy with or without radiation therapy in treating patients who have Hodgkin's lymphoma.

Conditions

• Lymphoma

Interventions

BIOLOGICAL

bleomycin sulfate

DRUG

ABVD regimen

DRUG

BEACOPP regimen

DRUG

epirubicin hydrochloride

DRUG

prednisone

DRUG

vinblastine sulfate

RADIATION

radiation therapy

Sponsors & Collaborators

• Lymphoma Study Association

  collaborator OTHER

• UNICANCER

  collaborator OTHER

• European Organisation for Research and Treatment of Cancer - EORTC

  lead NETWORK

Principal Investigators

• Jose Thomas, MD · University Hospital, Gasthuisberg

• H. Eghbali, MD · Institut Bergonié

• E.M. Noordijk, MD · Leiden University Medical Center

• Christophe Ferme · Centre Medical de Bligny

• Christian Gisselbrecht, MD · Hopital Saint-Louis

• Thierry O. Philip, MD · Centre Leon Berard

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Eligibility

Min Age

15 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1998-10-31

Primary Completion

2004-05-31

Countries

• Belgium
• France
• Italy
• Netherlands
• Poland
• Portugal
• Slovakia
• Slovenia
• Spain
• Switzerland

Study Locations