Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin's Lymphoma

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating stage III or stage IV Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens in treating patients who have stage III or stage IV Hodgkin's lymphoma.

Conditions

• Lymphoma

Interventions

BIOLOGICAL

bleomycin sulfate

BIOLOGICAL

filgrastim

BIOLOGICAL

pegfilgrastim

DRUG

ABVD regimen

DRUG

BEACOPP regimen

DRUG

cyclophosphamide

DRUG

dacarbazine

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

prednisone

DRUG

procarbazine hydrochloride

DRUG

vinblastine sulfate

DRUG

vincristine sulfate

Sponsors & Collaborators

• Lymphoma Trials Office

  collaborator OTHER

• Lymphoma Study Association

  collaborator OTHER

• Grup per l'Estudi dels Limfomes de Catalunya i Balears

  collaborator OTHER

• NCIC Clinical Trials Group

  collaborator NETWORK

• Australasian Leukaemia and Lymphoma Group

  collaborator OTHER

• Nordic Lymphoma Group

  collaborator NETWORK

• European Organisation for Research and Treatment of Cancer - EORTC

  lead NETWORK

Principal Investigators

• Patrice P. Carde, MD · Gustave Roussy, Cancer Campus, Grand Paris

• David C. Linch · Middlesex Hospital

• Marine Divine, MD · Centre Hospitalier Universitaire Henri Mondor

• Anna Sureda · Hospital de la Santa Cruz i Sant Pau

• Ralph M. Meyer, MD, FRCPC · Margaret and Charles Juravinski Cancer Centre

• David Ma, MD · St Vincent's Hospital

• Devinder Gill, MD · Princess Alexandra Hospital

• Bengt Glimelius, MD · Uppsala University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

16 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-08-31

Primary Completion

2010-01-31

Countries

• Australia
• Belgium
• Canada
• Croatia
• Czechia
• France
• Hungary
• Netherlands
• New Zealand
• Poland
• Spain
• Sweden
• United Kingdom

Study Locations