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RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease

NCT00002462 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 615

Last updated 2025-08-05

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with combination chemotherapy may kill more tumor cells.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with no radiation therapy following chemotherapy in treating patients with stage III or stage IV Hodgkin's disease.

Conditions

Interventions

BIOLOGICAL

bleomycin sulfate

DRUG

doxorubicin hydrochloride

DRUG

mechlorethamine hydrochloride

DRUG

prednisone

DRUG

procarbazine hydrochloride

DRUG

vinblastine sulfate

DRUG

vincristine sulfate

RADIATION

low-LET cobalt-60 gamma ray therapy

RADIATION

low-LET photon therapy

RADIATION

radiation therapy

Sponsors & Collaborators

  • European Organisation for Research and Treatment of Cancer - EORTC

    lead NETWORK

Principal Investigators

  • John Raemaekers, MD, PhD · Universitair Medisch Centrum St. Radboud - Nijmegen

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT

Eligibility

Min Age
15 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1989-09-30
Primary Completion
2000-05-31

Countries

  • Belgium
  • Egypt
  • France
  • Germany
  • Italy
  • Netherlands
  • Poland
  • Portugal
  • Slovenia

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00002462 on ClinicalTrials.gov