Chemotherapy Based on PET Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma

Summary

RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride, bleomycin sulfate, vinblastine, dacarbazine, cyclophosphamide, etoposide, procarbazine hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells. Comparing results of imaging procedures, such as PET scans and CT scans, done before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.

PURPOSE: This phase II clinical trial studies how well chemotherapy based on PET/CT scan works in treating patients with stage I or stage II Hodgkin lymphoma.

Conditions

• Lymphoma

Interventions

DRUG

Doxorubicin

IV

DRUG

Bleomycin

IV

DRUG

Vinblastine

IV

DIAGNOSTIC_TEST

PET

fludeoxyglucose F 18 Imaging exam

RADIATION

INRT

selective external radiation therapy

DRUG

Dacarbazine

IV

DRUG

Etoposide

IV

DRUG

Cyclophosphamide

May be given orally, IV push, or by IV infusion

DRUG

Vincristine

IV

DRUG

Procarbazine

PO

DRUG

Prednisone

PO

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• ECOG-ACRIN Cancer Research Group

  lead NETWORK

Principal Investigators

• Ranjana Advani, MD · Stanford University

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-05-24

Primary Completion

2015-04-09

Completion

2018-05-18

FDA Drug

Yes

Countries

• United States

Study Locations