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Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

NCT00000259 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2015-05-28

No results posted yet for this study

Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Conditions

  • Opioid-Related Disorders
  • Substance-Related Disorders

Interventions

DRUG

15 % Nitrous oxide

DRUG

0.3 % Sevoflurane

DRUG

30% Nitrous oxide

DRUG

0.6% Sevoflurane

OTHER

Placebo

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Chicago

    lead OTHER

Principal Investigators

  • James Zacny, Ph.D. · University of Chicago

Study Design

Allocation
NON_RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
39 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1996-08-31
Primary Completion
1997-11-30
Completion
1997-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000259 on ClinicalTrials.gov