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Isoflurane at Subanesthetic Concentrations - 6

NCT00000254 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2015-05-28

No results posted yet for this study

Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Conditions

  • Opioid-Related Disorders
  • Substance-Related Disorders

Interventions

DRUG

40% Nitrous oxide

Used as pain assay positive control

OTHER

Sham comparator

0% isoflurane in oxygen

DRUG

0.2% isoflurane

DRUG

0.4% isoflurane

DRUG

0.6% isoflurane

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Chicago

    lead OTHER

Principal Investigators

  • James Zacny, Ph.D. · University of Chicago

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
34 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1995-01-31
Primary Completion
1995-09-30
Completion
1995-09-30

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000254 on ClinicalTrials.gov