Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance
NCT00522587 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2013-01-30
Summary
During this study, the pharmacodynamic interactions between sevoflurane and remifentanil will be studied.
Conditions
- Anesthesia
Interventions
- DRUG
-
Fixed sevoflurane dose 1
Dose 1 of sevoflurane
- DRUG
-
Fixed sevoflurane dose 2
Dose 2 of sevoflurane
- DRUG
-
Fixed sevoflurane dose 3
Dose 3 of sevoflurane
- DRUG
-
Fixed sevoflurane dose 4
Dose 4 of sevoflurane
- DRUG
-
Fixed sevoflurane dose 5
Dose 5 of sevoflurane
- DRUG
-
Fixed sevoflurane dose 6
Dose 6 of sevoflurane
- DRUG
-
Fixed remifentanil dose 1
Dose 1 of remifentanil
- DRUG
-
Fixed remifentanil dose 2
Dose 2 of remifentanil
- DRUG
-
Fixed remifentanil dose 3
Dose 3 of remifentanil
- DRUG
-
Fixed remifentanil dose 4
Dose 4 of remifentanil
- DRUG
-
Fixed remifentanil dose 5
Dose 5 of remifentanil
- DRUG
-
Fixed remifentanil dose 6
Dose 6 of remifentanil
Sponsors & Collaborators
-
University Hospital, Ghent
lead OTHER
Principal Investigators
-
Michel Struys, MD, PhD · University Hospital, Ghent
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-04-30
- Primary Completion
- 2009-07-31
- Completion
- 2011-12-31
Countries
- Belgium
Study Locations
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