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Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

NCT00717574 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2017-07-31

Study results available
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Summary

The study hypothesizes that adding 60% nitrous oxide to a steady state sevoflurance or propofol anesthetic will lead to a decrease in both BIS and Entropy indices during a constant level of surgical stimulus

Conditions

  • Deep Sedation
  • Anesthesia, General

Interventions

DRUG

Sevoflurane group

Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture.

DRUG

Propofol group

Addition of 60% nitrous oxide for 20 minutes duration, then back to 1:1 oxygen/air mixture.

Sponsors & Collaborators

  • University of Oklahoma

    lead OTHER

Principal Investigators

  • Mehmet S Ozcan, M.D. · Univeristy of Illinois Chicago

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00717574 on ClinicalTrials.gov