SEvoflurane for Sedation in ARds

Summary

This study evaluates whether a sedation with inhaled sevoflurane will decrease mortality and increase time off the ventilator at 28 days in patients with acute respiratory distress syndrome (ARDS).

Half of the patients will receive inhaled sedation with sevoflurane and the other half will receive intravenous sedation with propofol.

Conditions

• Acute Respiratory Distress Syndrome

Interventions

DRUG

Inhaled sedation with sevoflurane

Inhaled sedation with sevoflurane using the Anesthesia Conserving Device (AnaConDa-S, Sedana Medical, Danderyd, Sweden).

DRUG

intravenous sedation with propofol

intravenous sedation with propofol, as already routinely used in participating ICUs.

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand

  lead OTHER

Principal Investigators

• Alexandre Lautrette · Centre Jean-Perrin Clermont-Ferrand

• Julien Pottecher · CHU Strasbourg

• Franck Verdonk · APHP - Saint-Antoine

• Christophe Vinsonneau · CH Béthune

• Pierre-Marie Bertrand · CH Cannes

• Mehran Monchi · CH Melun-Sénart

• Joël Cousson · CHU REIMS

• Julien Maizel · CHU Amiens

• Erwan L'Her · CHU Brest

• Belaïd Bouhemad · CHU Dijon

• Boris Jung · CHU Montpellier - Lapeyronie

• Claire Dahyot-Fizelier · CHU Poitiers

• Claire Lhommet · Hopital Diaconesses - La Croix Simon

• Caroline Varillon · CH Dunkerque

• Arthur Durand · CHU Lille

• Marc Gainnier · APHM - La Timone

• Fabien Lambiotte · Hospital Valenciennes

• Julien Lorber · Hospital, Saint Nazaire

• Delphine Brégeaud · HOSPITAL, SAINTES

• Aziz Berrouba · Hospital Martigues

• Julio Badie · Hospital Belfort

• Alexandre Conia · HOSPITAL, CHARTRES

• François Thouy · University Hospital, Clermont-Ferrand

• Matthieu Jabaudon · University Hospital, Clermont-Ferrand

• Raïko Blondonnet · University Hospital, Clermont-Ferrand

• Jean-Michel Constantin · APHP - La Pitié Salpêtrière

• Antoine Roquilly · Nantes University Hospital

• Samir Jaber · CHU Montpellier - Saint-Eloi

• Virginie Lemiale · APHP - Saint-Louis

• Carole Ichai · CHU NICE

• Lionel Velly · APHM - La Timone

• Stéphanie Bulyez · CHU Nîmes

• Sigismond Lasocki · University Hospital, Angers

• Jean-Pierre Quenot · CHU Dijon

• Thomas Lebouvier · CHU Rennes

• François Legay · CH Brieuc

• Arnaud W. Thille · CHU Poitiers

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-05-03

Primary Completion

2023-10-31

Completion

2024-10-02

Countries

• France

Study Locations