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Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding

NCT07638696 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2026-06-11

No results posted yet for this study

Summary

This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed. While standard intermittent fasting allows water intake, Ramadan dry fasting involves total restriction of both food and fluids from dawn to sunset.

Researchers want to see if the combined effects of fluid restriction and natural daily body rhythms during Ramadan trigger a stronger cellular cleanup process (called mitophagy) compared to standard 16:8 water-permitted fasting. The study will look at how these fasting habits change blood markers related to mitochondrial DNA and metabolic health across a 30-day period. This research will help determine if dry fasting offers distinct biological benefits for cellular renewal.

Conditions

  • Mitochondrial Degradation
  • Autophagy
  • Fasting
  • Healthy Volunteers
  • Metabolic Adaptation

Interventions

BEHAVIORAL

Ramadan Intermittent Dry Fasting (Sawm)

Total fluid and nutrient restriction enforced daily from dawn (Fajr) to sunset (Maghrib) for 30 consecutive days. Food and fluid consumption are restricted to the nocturnal period

BEHAVIORAL

16:8 Time-Restricted Feeding (TRF)

A 16-hour daily fasting window where calorie-containing foods and beverages are completely restricted. Fluid intake (such as water or uncaloried drinks) is permitted throughout the fasting period

Sponsors & Collaborators

  • Bahcesehir Cyprus University

    lead OTHER

Principal Investigators

  • Berna Uzun · Operational Research Institute in Healthcare, Near East University, Nicosia, TRNC, Mersin 10, Turkey

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2027-01-15
Primary Completion
2027-04-15
Completion
2027-04-30

Countries

  • Cyprus

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07638696 on ClinicalTrials.gov