Long-term Fasting: Multi-system Adaptations in Humans

Summary

The aim of this trial is to investigate the effects of long-term fasting on size, mass, composition and function of metabolic active tissues in several organs that reexpand possibly rejuvenated after 1-4 months. Additionally, the lipid metabolism is investigated in depth.

Conditions

• Fasting

Interventions

OTHER

Long-term fasting according to the Buchinger Wilhelmi fasting program

the participants will undergo a fasting program that includes the daily intake of 250 kcal under medical supervision

Sponsors & Collaborators

• Buchinger Wilhelmi Clinic

  collaborator UNKNOWN

• Claude Bernard University

  collaborator OTHER

• University of Milan

  collaborator OTHER

• Omegametrix GmbH

  collaborator UNKNOWN

• King's College London

  collaborator OTHER

• MVZ Humangenetik Ulm

  collaborator UNKNOWN

• University of Graz

  collaborator OTHER

• Leiden University Medical Center

  collaborator OTHER

• MVZ Labor Ravensburg

  collaborator UNKNOWN

• ETH Zurich

  collaborator OTHER

• Buchinger Wilhelmi Development & Holding GmbH

  lead OTHER

Principal Investigators

• Françoise Wilhelmi de Toledo, Dr · Buchinger Wilhelmi Clinic

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

20 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-09-10

Primary Completion

2022-08-30

Completion

2022-12-31

Countries

• Germany

Study Locations