Evaluation of the Ketogenic Potential of Different Diet Supplements

Summary

Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.

Conditions

• Healthy Adults

Interventions

DIETARY_SUPPLEMENT

Control

Visit corresponding to a standardize breakfast taken alone (control visit) followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Leucine

Visit corresponding to a standardize breakfast with 5 g of leucine followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Butyrate -

Visit corresponding to a standardize breakfast with 3.6 g of butyrate followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Butyrate +

Visit corresponding to a standardize breakfast with 7.2 g of butyrate followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Octanoate -

Visit corresponding to a standardize breakfast with 5 g of octanoate followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Octanoate +

Visit corresponding to a standardize breakfast with 10 g of octanoate followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Carnitine

Visit corresponding to a standardize breakfast with 1.95 g of carnitine followed by a period of 4-hour with multiple blood sampling.

DIETARY_SUPPLEMENT

Butter fraction

Visit corresponding to a standardize breakfast with 65 g of butter fraction followed by a period of 4-hour with multiple blood sampling.

Sponsors & Collaborators

• Université de Sherbrooke

  lead OTHER

Principal Investigators

• Stephen Cunnane, PhD · Research Centre on Aging CSSS-IUGS - CIUSSS de l'Estrie - CHUS

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-07-31

Primary Completion

2015-06-30

Completion

2015-06-30

Countries

• Canada

Study Locations