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Time Course for Fasting-induced Autophagy in Humans

NCT04842864 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2022-08-26

No results posted yet for this study

Summary

Autophagy, which involves the degradation of aged or damaged cellular components, has been shown to extend healthspan and lifespan in multiple organisms, including flies, worms, and mice. Research has also demonstrated that autophagy declines with age in these simpler experimental models. However, human studies are lacking. Our study seeks to determine whether fasting, a robust stimulus of autophagy, upregulates autophagy in humans, and whether autophagy is reduced in healthy older people compared to healthy younger individuals.

Conditions

  • Fasting
  • Autophagy
  • Aging Well
  • Ketosis, Metabolic

Interventions

BEHAVIORAL

Fasting

23 hours fasting

Sponsors & Collaborators

  • Glenn Foundation for Medical Research

    collaborator UNKNOWN

  • Montefiore Medical Center

    lead OTHER

Principal Investigators

  • Jill Crandall, MD · Albert Einstein College of Medicine

  • Nir Barzilai, MD · Albert Einstein College of Medicine

  • Rajat Singh, MD · Albert Einstein College of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-19
Primary Completion
2022-05-31
Completion
2023-02-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04842864 on ClinicalTrials.gov