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Physiological Effects of External PEEP in Controlled Mechanical Ventiated Patients With autoPEEP

NCT07611409 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-05-28

No results posted yet for this study

Summary

This experimental physiologic study is conducted to determine the effect of different mechanical ventilation settings (in terms of positive end-expiratory pressure) on patients receiving mechanical ventilation with expiratory flow obstruction and autoPEEP. The main question it aims to answer In patients with autoPEEP, what is the effect of applying external PEEP on gas exchange and the lung emptying pattern in patients with total ventilatory support? Participants must comply:

\- Age \> 17 years.

* Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 \> 90%, for more than 12 hours.
* No contraindications for abdominal compression.
* Presence of autoPEEP greater than 3 cmH2O measured in mechanical ventilation with total support and ZEEP.
* Total mechanical respiratory support, without respiratory muscle activity (inspiratory or expiratory).

Conditions

  • Obstructive Airway Diseases

Interventions

OTHER

PEEP titration

External PEEP will be increased by 3 cmH₂O, from 0 to 15 cmH₂O.

Sponsors & Collaborators

  • Hospital Donación Francisco Santojanni

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-10
Primary Completion
2026-12-20
Completion
2027-04-10

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07611409 on ClinicalTrials.gov