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Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging

NCT07590089 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-05-15

No results posted yet for this study

Summary

This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging. Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth, and aging-related inflammation may influence its progression.

The study will include participants with different stages of periodontitis as well as healthy individuals. Clinical periodontal parameters will be recorded, and biological samples such as saliva or gingival crevicular fluid will be collected to measure levels of NLRP3 inflammasome components and inflammatory markers.

The results of this study may help improve understanding of the role of inflammation and aging in periodontal disease and could contribute to better diagnosis and treatment strategies.

Conditions

  • Periodontitis
  • Periodontitis Stage I
  • Periodontitis Stage II
  • Periodontitis Stage III

Sponsors & Collaborators

  • Misr University for Science and Technology

    lead OTHER

Principal Investigators

  • RANDA SHAEBAN SHINKADA, MASTER · RANDA SHAEBAN SHINKADA. MUST

  • RADWA Mohamed, PHD · RADWA MOHAMED

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2025-12-31
Completion
2026-01-20

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07590089 on ClinicalTrials.gov