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Long-term Risk of Cardiovascular Disease in Living Kidney Donors

NCT07431515 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50000

Last updated 2026-03-17

No results posted yet for this study

Summary

The investigative team will conduct a population-based, matched retrospective cohort study across Ontario, Alberta, and British Columbia using linked administrative healthcare databases to evaluate the long-term risk of major adverse cardiovascular events (MACE) among living kidney donors compared with matched healthy nondonors. Living kidney donors who donated between 1992 and 2024 will be included and matched 1:10 to a carefully selected population of nondonors based on key demographic and clinical characteristics. The primary outcome is a composite of cardiovascular death, hospital admission for myocardial infarction, or hospital admission for ischaemic stroke. Secondary outcomes will examine each component of the composite separately and all-cause mortality. The results will provide evidence to inform clinical guidelines, support informed decision-making for potential donors and recipients, and guide counselling by transplant clinicians.

Conditions

  • Living Donor Nephrectomy
  • Living Kidney Donation
  • Living Kidney Donor
  • Living Kidney Donors
  • Cardiovascular Disease
  • Major Adverse Cardiovascular Events (MACE)
  • Mortality

Interventions

PROCEDURE

Nephrectomy

Receipt of a nephrectomy for living kidney donation

Sponsors & Collaborators

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
105 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1992-07-01
Primary Completion
2024-03-31
Completion
2025-03-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07431515 on ClinicalTrials.gov