A Prospective UK Multicentre Study of Kidney Donors

Summary

Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death. This may be because kidney disease causes stiffening of the arteries in the body which means that the heart and brain are damaged by high blood pressure. By studying patients before and after the removal of a kidney (uni-nephrectomy) for transplantation the investigators will find out for the first time in man the effect of an isolated reduction in kidney function on the structure and function of the cardiovascular system.

Conditions

• Living Kidney Donors

Interventions

OTHER

Nephrectomy

Nephrectomy for the purposes of living kidney donation

Sponsors & Collaborators

• British Heart Foundation

  collaborator OTHER

• University Hospital Birmingham NHS Foundation Trust

  collaborator OTHER

• North Bristol NHS Trust

  collaborator OTHER

• University Hospitals Coventry and Warwickshire NHS Trust

  collaborator OTHER

• St. George's Hospital, London

  collaborator OTHER

• Glasgow Western Infirmary

  collaborator OTHER

• Sheffield Teaching Hospitals NHS Foundation Trust

  collaborator OTHER

• Manchester University NHS Foundation Trust

  collaborator OTHER_GOV

• Cambridge University Hospitals NHS Foundation Trust

  lead OTHER

Principal Investigators

• John Cockcroft, PhD · Cardiff

• Ian B Wilkinson · Cambridge Heart Inc.

• Jonathan N Townend · Birmingham

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-02-28

Primary Completion

2016-06-30

Completion

2017-03-31

Countries

• United Kingdom

Study Locations