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Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation

NCT01564966 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2012-03-29

No results posted yet for this study

Summary

* A reduce in renal mass may result in remnant single nephron hyperfiltration, with associated proteinuria and an accelerated loss of kidney function.
* Live-donor kidney transplantation is generally considered the best choice for patients who have renal failure and are awaiting transplantation, because these kidneys function better than kidneys from deceased donors, and waiting times for deceased-donor transplants are long
* Although several studies have shown that kidney donation has low short-term morbidity and mortality, the data on long-term outcomes are much less complete.
* This study is designed to prospectively evaluate the effects of unilateral nephrectomy on cardiovascular-renal functions of donors after living kidney donation: the development of hypertension, albuminuria, renal failure, inflammatory and endothelial changes.

Conditions

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Principal Investigators

  • Alaattin Yildiz, Professor of Medicine, MD · Istanbul University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-04-30
Primary Completion
2011-09-30
Completion
2011-12-31

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01564966 on ClinicalTrials.gov