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Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors

NCT00846729 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2018-04-30

No results posted yet for this study

Summary

It is our purpose in this study to compare the kidney structure and function of older patients to that of young patients before and after removal of a single kidney for transplant donation and to examine the remaining kidney's ability to adapt and maintain function over time. More specifically, we aim to examine the effect of uninephrectomy on adaptive hyperfiltration in the remaining kidney. A secondary aim is to investigate whether subjects in the aging population undergo compensation to the same extent as younger subjects. We will also examine the compensatory rise in GFR (glomerular filtration rate) that follows uninephrectomy in both groups, and, again, compare the results in the aged versus young subjects. This will help in delineating the extent to which the aging population can be a potential source of living kidney donors for kidney transplantation.

It is also our purpose with this study to refine the tests to be used in the donor evaluation process so as to accurately identify ideal candidates for safe kidney donation.

Conditions

Interventions

PROCEDURE

CT angiogram of the remaining kidney.

PROCEDURE

Kidney Function study using Iothalamate & PAH as clearance markers

Sponsors & Collaborators

Principal Investigators

  • Bryan D Myers · Stanford University

  • Jane C. Tan · Stanford University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-03-31
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00846729 on ClinicalTrials.gov