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Fracture Risk in Living Kidney Donors

NCT07401953 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50000

Last updated 2026-02-13

No results posted yet for this study

Summary

This study will be a population-based, matched retrospective cohort study using linked administrative healthcare databases from Ontario, Alberta, and British Columbia to evaluate the long-term risk of fractures among living kidney donors compared with a healthy cohort of nondonors. Living kidney donors who donated between 1992 and 2024 will be included and matched 1:10 to a carefully selected population of nondonors based on key demographic and clinical characteristics. The primary outcome is a composite of incident hip, femoral shaft, humeral, wrist/forearm, and pelvic fractures. Secondary outcomes will examine each fracture site separately. The results will provide evidence to inform clinical guidelines, support informed decision-making for potential donors and recipients, and guide counselling by transplant clinicians.

Conditions

  • Living Kidney Donor
  • Living Kidney Donation
  • Fractures
  • Nephrectomy,Kidney Donation
  • Fragility Fractures

Interventions

PROCEDURE

Nephrectomy

Receipt of a nephrectomy for living kidney donation

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
105 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1992-07-01
Primary Completion
2024-03-31
Completion
2025-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07401953 on ClinicalTrials.gov