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The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults

NCT07388121 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2026-02-04

No results posted yet for this study

Summary

The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables. Our bodies cannot make them on their own, but we need them to function correctly. Vitamins play various roles, including supporting the immune system and assisting with energy production. Some vitamins in our diet can reach the large intestine, where they may be used by gut bacteria to promote their growth. In this study, we aim to investigate how our gut bacteria interact with vitamin C and how this interaction affects their growth and activity.

For this study, participants will follow their habitual diet for one-week (run-in period), followed by two consecutive two-week supplementation periods in which they will first take a moderate dose (200 mg/day) and then a high-dose (1000 mg/day) of vitamin C. A final one-week period follow up period will involve a return to their habitual diet. Faecal, blood and urine samples will be collected at the start and end of each supplementation period to explore changes in gut microbiota composition, activity and markers of inflammation.

Conditions

  • Short Chain Fatty Acids Concentration in Stools
  • Gut Microbiota Diversity and Composition

Interventions

DIETARY_SUPPLEMENT

Moderate Vitamin C dose (200 mg)

200 mg of vitamin C provided as a chewable tablet, taken orally daily for two weeks

DIETARY_SUPPLEMENT

High-dose vitamin C supplementation (1000 mg)

1000 mg of Vitamin C provided as a chewable tablet, taken orally daily for two weeks

OTHER

Habitual diet (run in period)

this is a run-in period where participants consume their habitual diet for one week

Sponsors & Collaborators

  • Professor Konstantinos Gerasimidis, University of Glasgow

    collaborator UNKNOWN

  • University of Glasgow

    lead OTHER

Principal Investigators

  • Athanasios Koutsos, PhD · Human Nutrition, School of Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2026-07-01
Completion
2026-07-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07388121 on ClinicalTrials.gov