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Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults

NCT07178353 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-09-22

No results posted yet for this study

Summary

The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:

How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?

Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:

* Magnetic resonance imaging of the thigh muscles
* Strength testing of the thigh muscles
* Insulin sensitivity testing in response to a mixed meal
* Exogenous glucose oxidation in response to a mixed meal
* Muscle biopsies from the thigh muscles
* Blood samples

Conditions

Interventions

OTHER

Bedrest

5 days of strict bedrest. Participants are allowed to sit up in bed, but will perform any bathing or bathroom activities in a wheelchair.

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Queen's University

    lead OTHER

Principal Investigators

  • Chris McGlory, PhD. · Queen's University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-30
Primary Completion
2026-06-30
Completion
2027-06-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07178353 on ClinicalTrials.gov