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The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers

NCT07062562 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2025-07-14

No results posted yet for this study

Summary

The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are:

* Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest?
* Does repeated NMES sessions offer protective effects on muscle mass and function during extended periods of inactivity?

Researchers will compare sham electrical electrostimulation, electrical stimulation and electrical stimulation + protein groups to see if whole-body electrostimulation combined with protein intake offers the greatest improvement in muscle protein metabolism and muscle preservation.

Participants will:

* Undergo 3 days of bed rest while receiving one of the following interventions:

* Sham-NMES followed by standard nutrition (CON)
* Whole-body NMES followed by standard nutrition(NMES)
* Whole-body NMES followed by a bolus of 20g protein (NMES+PRO)
* Receive heavy water (D2O) to assess body water turnover.
* Undergo leg extension exercises to assess muscle function.
* Have quadriceps muscle thickness measured via ultrasound.
* Provide saliva samples for analysis.
* Have calf circumference measured to monitor changes in muscle mass.

Conditions

  • Muscle Wasting

Interventions

OTHER

Sham (No Treatment)

A placebo treatment in which no actual electrical stimulation is delivered, serving as a control for the active NMES.

OTHER

NMES

Active neuromuscular electrical stimulation applied to the entire body to induce muscle contractions through small electric currents.

DIETARY_SUPPLEMENT

Protein bolus (20g)

A bolus dose of 20 grams of protein provided after the NMES intervention to assess the combined effect of muscle stimulation and protein intake on muscle protein metabolism.

OTHER

Standard nutrition

Provision of a normal Western standardized diet.

Sponsors & Collaborators

  • Wageningen University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-22
Primary Completion
2027-05-31
Completion
2027-05-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07062562 on ClinicalTrials.gov