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Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine

NCT07050277 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-12-29

No results posted yet for this study

Summary

Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs. The multimodal approach, including single shot or continuous nerve blocks with catheters and spinal or epidural morphine, is a stablished strategy. Although the administration of intrathecal morphine (IM) has been shown to significantly reduce pain scores, it is not free of adverse effects. Postoperative urinary retention (POUR) is possible and might increase the risk of periprosthetic infection. The purpose of this study is to compare patients undergoing rTKAS under spinal anesthesia with IM to patients undergoing the same procedure, under the same anesthetic technique, but with no IM, for POUR and postoperative pain related outcomes. All patients will have single shot and continuous adductor canal block (CACB) and single shot IPACK (interspace between the popliteal artery and the posterior knee capsule) block. The hypothesis is that postoperative pain control is comparable between the groups, with lower incidence of POUR in patients with no IM given.

Conditions

  • Arthroplasties, Knee Replacement
  • Nerve Block
  • Urinary Retention Postoperative
  • Anesthesia, Spinal

Interventions

DRUG

Intrathecal Morphine

Intrathecal morphine

DRUG

No Intrathecal Morphine

No Intrathecal Morphine

Sponsors & Collaborators

  • University of Toronto

    lead OTHER

Principal Investigators

  • Hermann dos Santos Fernandes, MD, PhD · Department of Anesthesia and Pain Management, Mount Sinai Hospital Assistant

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-24
Primary Completion
2027-07-01
Completion
2027-08-01

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07050277 on ClinicalTrials.gov