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Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

NCT00797264 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2013-04-11

No results posted yet for this study

Summary

Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

Conditions

  • Arthroplasty, Replacement, Hip

Interventions

DRUG

Ketamine-Morphine

Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)

DRUG

Morphine

Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)

DRUG

Postoperative PCA of Ketamine and morphine

Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Philippe SITBON, MD · Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00797264 on ClinicalTrials.gov