Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments

Summary

The aim of this study was to investigate the effects of different oxygen therapy modalities (including nasal cannula oxygen, mask oxygen and high-flow nasal cannula oxygen) on the correlation between Nasal Pressure and Esophageal Pressure by means of a prospective physiological study, to assess the dynamic changes of nasal pressure and esophageal pressure and their underlying mechanisms under different conditions of oxygen therapy, to analyse the effects of oxygen therapy parameters on the relationship between the two, and to explore the feasibility of nasal pressure as a non-invasive monitoring indicator, in order to replaceor supplement esophageal manometry in clinical practice, especially in patients with respiratory distress and instability.Meanwhile, this study will also evaluate the effects of different oxygen therapy modalities on patients' respiratory mechanics and comfort, provide a scientific basis for the clinical selection of individualised oxygen therapy regimens, and ultimately provide new physiological evidence for the management of oxygen therapy in patients with acute respiratory failure in the intensive care unit (ICU) and outside the ICU, promote the development of non-invasive monitoring technology, and improve the clinical prognosis and therapeutic experience of patients.

Conditions

• Critical Care
• Inspiratory Effort

Interventions

PROCEDURE

HFNC:50L/min

Under high-flow oxygen therapy at a flow rate of 50 L/min, record/monitor for 5 minutes

PROCEDURE

HFNC:flow=40L/min

Under high-flow oxygen therapy at a flow rate of 40 L/min, record/monitor for 5 minutes.

PROCEDURE

HFNC:flow=30L/min

Under high-flow oxygen therapy at a flow rate of 30 L/min, record/monitor for 5 minutes.

PROCEDURE

Face mask oxygen:8L/min

Under face mask oxygen at a flow rate of 8 L/min, record/monitor for 5 minutes.

PROCEDURE

Face mask oxygen:5L/min

Under face mask oxygen at a flow rate of 5 L/min, record/monitor for 5 minutes.

PROCEDURE

Nasal cannula oxygen:5L/min

Under nasal cannula oxygen at a flow rate of 5 L/min, record/monitor for 5 minutes.

PROCEDURE

Nasal cannula oxygen:3L/min

Under nasal cannula oxygen at a flow rate of 3 L/min, record/monitor for 5 minutes.

Sponsors & Collaborators

• Jian-Xin Zhou

  lead OTHER

Principal Investigators

• Jian-Xin Zhou, MD, PhD · Capital Medical University

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-05-20

Primary Completion

2025-11-30

Completion

2025-12-30

Countries

• China

Study Locations