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Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials

NCT06816706 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-03-21

No results posted yet for this study

Summary

Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.

Conditions

  • Critical Care
  • Oxygen Therapy
  • Mechanical Ventilation

Interventions

PROCEDURE

Modified high flow tracheal oxygen-40L/min

Modified high-flow tracheal oxygen with a flow rate of 40L/min will be performed.

PROCEDURE

Standard high flow tracheal oxygen-40L/min

Standard high-flow tracheal oxygen with a flow rate of 40 L/min will be performed.

PROCEDURE

T-piece

T-piece will be performed.

PROCEDURE

Modified high-flow tracheal oxygen-60L/min

Modified high-flow tracheal oxygen with a flow rate of 60L/min will be performed.

PROCEDURE

Standard high-flow tracheal oxygen-60 L/min

Standard high-flow tracheal oxygen with a flow rate of 60 L/min will be performed.

Sponsors & Collaborators

  • Jian-Xin Zhou

    lead OTHER

Principal Investigators

  • Jian-Xin Zhou, MD, PhD · Capital Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-11-30
Completion
2025-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06816706 on ClinicalTrials.gov