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HFNC vs NPPV After Early Extubation for Patients With COPD

NCT04156139 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 502

Last updated 2020-01-23

No results posted yet for this study

Summary

High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with acute hypoxemic respiratory failure.However, the efficacy of early postextubation sequential HFNC in COPD patients with hypercapnic respiratory failure is inconclusive.

Conditions

  • COPD
  • Hypercapnic Respiratory Failure

Interventions

DEVICE

HFNC

The gas flow rate was set at 45\~55 L/min. The inhaled oxygen concentration will be dynamically adjusted to maintain SpO2 ≥ 92%. The temperature will be set at 37 °C.

DEVICE

NPPV

The PEEP is initially set as 5 cm H2O, the inspiratory pressure is 10 cm H2O, and the target tidal volume is 6-8 ml/kg.

Sponsors & Collaborators

  • Peking University Health Science Center

    collaborator OTHER

  • Chinese PLA General Hospital

    lead OTHER

Principal Investigators

  • XIE Lixin, MD · Chinese PLA General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-12-18
Primary Completion
2022-05-01
Completion
2022-11-01

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04156139 on ClinicalTrials.gov