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Validation and Simplification of the Retinol Isotope Dilution Technique in Burkinabe Schoolchildren

NCT06759493 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 158

Last updated 2025-03-18

No results posted yet for this study

Summary

Two cross-sectional, repeated-pass, community-based studies will be carried out during the school year. The first study will be conducted from November to December. This period corresponds to the end of the rainy season and the end of the mango season, which is one of the main sources of vitamin A in the Orodara region.

The second survey will be carried out 5 to 6 months (April-May of the following year) after data collection for the first study, corresponding to the mango season. The same schoolchildren recruited during the first phase of data collection (5 to 6 months earlier) will be the participants in the second study. The interest of this study is to use nuclear techniques to implement a strategy for the precise and accurate determination of Vitamin A status in order to reinforce existing Vitamin A interventions and policies.

Conditions

Interventions

DIAGNOSTIC_TEST

Retinol isotope dilution technique

A group of 60 school children will be recruited through a stratified sampling. To this first group of 60 school children a retinol isotope dilution (RID) test for total body store assessment will be applied. The remaining 98 school children will be recruited according to stratified sampling and divided into two groups of 49 children (females and males). To these groups of children, the modified relative dose response (MRDR) test, a qualitative measure of vitamin A status will be used to investigate the absorption of 3,4-didehydroretinyl acetate in oil.

Sponsors & Collaborators

  • International Atomic Energy Agency (IAEA)

    collaborator UNKNOWN

  • Institut de Recherche en Sciences de la Sante, Burkina Faso

    lead OTHER_GOV

Principal Investigators

  • Augustin N. ZEBA, PhD · Institut de Recherche en Sciences de la Santé

  • Sherry A. TANUMIHARDJO, PhD · University of Madison - Wisconsin

Eligibility

Min Age
7 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-11-21
Primary Completion
2025-04-30
Completion
2025-06-30

Countries

  • Burkina Faso

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06759493 on ClinicalTrials.gov