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Using Stable Isotope Techniques to Monitor & Assess the Vitamin A Status of Children Susceptible to Infection

NCT03194724 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2017-06-21

No results posted yet for this study

Summary

The relationship between infections and malnutrition is synergistic, each further compromising the outcome of the other. Malnutrition compromises natural immunity leading to increased susceptibility to infections, more frequent and prolonged disease episodes, and increased severity of disease. Likewise, infections can aggravate or precipitate malnutrition through decreased appetite and food intake, nutrient malabsorption, nutrient loss or increased metabolic needs. Severe malnutrition often masks symptoms and signs of infectious diseases making prompt clinical diagnosis and treatment very difficult. Another issue is that infections (as well as overweight and obesity status) affect nutritional biomarkers making it difficult to assess the real magnitude of some nutritional problems. This is the case of vitamin A. Vitamin A deficiency is defined to be of severe public health importance if 20% or more of a defined population has a serum retinol concentration of less than 0.7 µmol/L.

Conditions

  • Assessment of Vitamin A Status of Children

Interventions

OTHER

Vitamin A supplementation

Bi annual vitamin A supplementation programme

Sponsors & Collaborators

  • Netherlands: Ministry of Health, Welfare and Sports

    collaborator OTHER_GOV

  • UNICEF

    collaborator OTHER

  • University of Botswana

    collaborator OTHER

  • National Food Technology Research Centre, Botswana

    lead OTHER_GOV

Eligibility

Min Age
3 Years
Max Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2017-12-31
Completion
2018-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03194724 on ClinicalTrials.gov