Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children

Summary

The purpose of this cluster-randomized trial is to examine whether daily consumption of β-carotene biofortified maize flour can reduce the prevalence of vitamin A deficiency and improve the vitamin A status and among 4-8 year old children in rural Zambia.

Conditions

• Vitamin A Deficiency
• Low Serum Retinol

Interventions

DIETARY_SUPPLEMENT

β-Carotene Biofortified Maize Flour

DIETARY_SUPPLEMENT

White Maize Flour

Sponsors & Collaborators

• National Food and Nutrition Commission, Zambia

  collaborator UNKNOWN

• Tropical Diseases Research Centre, Zambia

  collaborator OTHER_GOV

• HarvestPlus

  collaborator OTHER

• Canadian International Development Agency

  collaborator OTHER_GOV

• Zambia Agriculture Research Institute

  collaborator OTHER

• Johns Hopkins Bloomberg School of Public Health

  lead OTHER

Principal Investigators

• Amanda C Palmer, PhD · Johns Hopkins Bloomberg School of Public Health

• Rolf Klemm, DrPH · Johns Hopkins Bloomberg School of Public Health

• Kerry J Schulze, PhD · Johns Hopkins Bloomberg School of Public Health

• Alain Labrique, PhD · Johns Hopkins Bloomberg School of Public Health

• Parul Christian, DrPH · Johns Hopkins Bloomberg School of Public Health

• Sucheta Mehra, MS · Johns Hopkins Bloomberg School of Public Health

• Lee Shu-Fune Wu, MS · Johns Hopkins Bloomberg School of Public Health

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

4 Years

Max Age

8 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-08-31

Primary Completion

2013-03-31

Completion

2013-06-30

Countries

• Zambia

Study Locations