MedTrace Logo

Inflammation's Impact on Heart Disease and Diabetes

NCT06752018 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2025-02-03

No results posted yet for this study

Summary

The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents. Briefly, the study involves two populations: healthy volunteers and severely obese patients undergoing weight-loss surgery. The main questions the study seeks to address are:

1. To investigate if the therapeutic agents modulate the inflammatory response linked to obesity and cardiometabolic disease?
2. What underlying factors contribute to variations in individual responses?

Researchers will examine differences between healthy participants and those undergoing weight-loss surgery to assess the potential impact of weight loss on responsiveness and overall outcomes.

Participants will:

* Undergo initial testing to evaluate their baseline response.
* Provide samples during surgery for further analysis.
* Participate in follow-up assessments to track changes over time.

Conditions

Interventions

PROCEDURE

Gastric bypass

Roux-en-Y gastric bypass or sleeve gastrectomy

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Emma Börgeson, Dr., PhD, MSc · University of Aarhus

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-30
Primary Completion
2030-12-31
Completion
2030-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06752018 on ClinicalTrials.gov