Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

Summary

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Conditions

• Obesity

Interventions

PROCEDURE

Muscle Biopsy

This procedure is used to sample muscle cells from the leg Vastus Lateralis (thigh) muscle.

PROCEDURE

Adipose Biopsy

This procedure is used to sample fat tissue from the abdomen (belly).

OTHER

Glucose Clamp

In this test, we will measure the effect of insulin by giving you insulin and glucose (sugar) intravenously through an IV line in your arm.

OTHER

Accelerometer

The tri-axial accelerometer measure activity and uses those values to estimate the number of calories burned based on your height, weight, age, and gender. The monitor also evaluates physical effort and the body's response to different activities.

OTHER

Endurance Exercise

Visit the study site 3 times a week to engage in endurance exercise training for approximately 12 weeks. Each session will last approximately 75 minutes, and exercise group can choose to use either a stationary bike or a treadmill to complete the training.

OTHER

Physical activity/ dietary habits

Visit the study site bi-weekly to get weight measurements and speak to the study team about weight maintenance and participant physical activity/dietary habits.

OTHER

Heavy Water Labeling Period

Participants in both control groups will be required to drink heavy water, which is ordinary water that is enriched with deuterium (stable, non-radioactive isotope) and called deuterium-labeled water, for 12 weeks.

Sponsors & Collaborators

• Pennington Biomedical Research Center

  collaborator OTHER

• AdventHealth Translational Research Institute

  lead OTHER

Principal Investigators

• Lauren Sparks, PhD · AdventHealth Translational Research Institute

• Ursula White, PhD · Pennington Biomedical Research Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-09-11

Primary Completion

2029-04-30

Completion

2029-04-30

Countries

• United States

Study Locations