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Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus)

NCT01911091 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 56

Last updated 2026-03-30

No results posted yet for this study

Summary

The purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the beneficial effects of exercise.

Conditions

  • Obesity
  • Disorder of Lipid Storage and Metabolism
  • Lipid Metabolism Disorders
  • Metabolic Disorder

Interventions

BEHAVIORAL

Exercise

A 5-minute warm-up and a 5-minute cool-down prior to and following each exercise session, respectively. There will be alternating days of interval training and aerobic training. The interval training will be performed on an upright stationary bike, while the aerobic training will be performed on a treadmill. The interval training will consist of five-minute bouts of higher intensity alternated with 4 minutes of lower intensity for a total duration of 45 minutes. Intensity will increase each week. The aerobic training component will be fixed at a moderate intensity, but will increase in duration each week from 45 minutes to 75 minutes to 90 minutes during the third and final week.

Sponsors & Collaborators

  • Sanford-Burnham Medical Research Institute

    collaborator OTHER

  • Takeda

    collaborator INDUSTRY

  • AdventHealth Translational Research Institute

    lead OTHER

Principal Investigators

  • Lauren Sparks, PhD · Translational Research Institute for Metabolism and Diabetes

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-07-31
Primary Completion
2014-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01911091 on ClinicalTrials.gov