Exercise Training and Fat Metabolism in Postmenopausal Women

Summary

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Conditions

• Postmenopausal Symptoms
• Obesity
• Prediabetic State

Interventions

BEHAVIORAL

Resistance Exercise

200 Kcal worth of weightlifting, 3 times/week for 12 weeks

BEHAVIORAL

Endurance Exercise

200 Kcal worth of treadmill walking, 3 times/week for 12 weeks

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• Pennington Biomedical Research Center

  collaborator OTHER

• University of Arkansas

  collaborator OTHER

• Florida State University

  lead OTHER

Principal Investigators

• Robert C Hickner, PhD · Florida State University

• Michael J Ormsbee, PhD · Florida State University

• Mostafa M Ali, PhD · Florida State University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-05-20

Primary Completion

2027-04-30

Completion

2027-04-30

Countries

• United States

Study Locations