Spastic Paraplegia - Centers of Excellence Research Network

Summary

The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).

Conditions

• Hereditary Spastic Paraplegia
• Primary Lateral Sclerosis
• SPG4
• SPG5A
• Spastic Paraplegia 4
• Spastic Paraplegia 5A
• Early Onset Hereditary Spastic Paraplegia
• Neuromuscular Diseases
• Spastic Paraplegia, Hereditary

Sponsors & Collaborators

• Massachusetts General Hospital

  collaborator OTHER

• Columbia University

  collaborator OTHER

• University of Miami

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• Baylor College of Medicine

  collaborator OTHER

• University of Texas Southwestern Medical Center

  collaborator OTHER

• University of Washington

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• Seattle Children's Hospital

  collaborator OTHER

• University of Iowa

  collaborator OTHER

• Boston Children's Hospital

  lead OTHER

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-04

Primary Completion

2026-06-04

Completion

2027-06-04

Countries

• United States

Study Locations