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Phenotype, Genotype & Biomarkers in ALS and Related Disorders

NCT02327845 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 700

Last updated 2025-07-03

No results posted yet for this study

Summary

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Conditions

  • Amyotrophic Lateral Sclerosis
  • Frontotemporal Dementia
  • Primary Lateral Sclerosis
  • Hereditary Spastic Paraplegia
  • Progressive Muscular Atrophy
  • Multisystem Proteinopathy

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • National Center for Advancing Translational Sciences (NCATS)

    collaborator NIH

  • St. Jude Children's Research Hospital

    collaborator OTHER

  • ALS Association

    collaborator OTHER

  • University of Miami

    lead OTHER

Principal Investigators

  • Michael Benatar, DPhil · University of Miami

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2026-07-31
Completion
2026-08-31

Countries

  • United States
  • Germany
  • South Africa

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02327845 on ClinicalTrials.gov