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Ketogenic Diet in Healthy Adults With Differing BMI

NCT06515912 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2026-04-15

No results posted yet for this study

Summary

The goal of this clinical trial is to examine the effect of the ketogenic diet over four weeks on blood lipid levels and risk factors for heart disease in adults with a healthy BMI compared to adults with a body mass index (BMI) in the range for obesity. The main questions it aims to answer are:

* Does the ketogenic diet cause larger increases in "bad cholesterol" (low density lipoprotein-cholesterol) in adults with a healthy BMI compared to adults with BMI in the range for obesity?
* Does the ketogenic diet cause larger decreases in vascular health in adults with a healthy BMI compared to adults with BMI in the range for obesity?

Participants will:

* Consume all of the study food provided and avoid intake of non-study foods during the 28-day diet period
* Visit the metabolic kitchen daily (Monday-Friday) to pick up meals
* Attend 5 fasting visits at the Clinical Research Center for testing

Conditions

Interventions

OTHER

Ketogenic Diet

A ketogenic diet with 5% carbohydrate, 18% protein, and 77% fat by percent kcal.

Sponsors & Collaborators

  • Penn State University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-29
Primary Completion
2026-03-31
Completion
2026-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06515912 on ClinicalTrials.gov